基础医学与临床 ›› 2019, Vol. 39 ›› Issue (8): 1200-1204.
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李贞燕,陈敏,戴日蕾,朱文婷,朱坤,曹春梅
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摘要: PI3K-Akt信号通路在细胞增殖和代谢中发挥了重要作用,并且PI3K-Akt信号通路在心脏保护机制——缺血预适应和缺血后适应中发挥重要作用。本文通过分析PI3K分子和Akt分子以及PI3K-Akt信号通路对心脏和血管生理性和病理性的影响,旨在了解其在心血管疾病中的作用。
关键词: PI3K, Akt, 急性心梗, 心血管疾病
Abstract: The PI3K-Akt signaling pathway plays an important role in cell proliferation and metabolism, and the PI3K-Akt signaling pathway plays an important role in cardiac protective mechanisms -- ischemic preconditioning and ischemic postconditioning. In this paper, the effects of PI3K molecule and Akt molecule, as well as PI3K-Akt signaling pathway on cardiac and vascular physiology and pathology were analyzed to understand its role in cardiovascular diseases.
Key words: PI3K, Akt, Acute myocardial infarction, Cardiovascular disease
中图分类号:
R331.3
李贞燕 陈敏 戴日蕾 朱文婷 朱坤 曹春梅. PI3K和Akt在心血管疾病中的作用[J]. 基础医学与临床, 2019, 39(8): 1200-1204.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2019/V39/I8/1200