基础医学与临床 ›› 2018, Vol. 38 ›› Issue (9): 1329-1332.
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陈骋1,张旋2,洪志鹏1
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摘要: 肺纤维化(PF)是多种原因引起的慢性间质性肺疾病,严重危害人类健康。多种细胞及分子被确认参与了PF形成的复杂过程,成为PF发病中较为重要的细胞和关键的致纤维化因子。这些关键细胞及分子可能成为抗PF药物作用的重要靶点,并为抗PF药物的研发提供一定的参考价值。
关键词: 肺纤维化, 细胞机制, 分子靶点
Abstract: Pulmonary fibrosis (PF) is a chronic disorder of the interstitial parenchyma that results in the disruption of lung architecture and is seriously harmful to human health. Various cells and molecules were found to participate in the complex process of PF formation, and identified as key factors to induce the incidence of PF. These cells and molecules may be important targets for anti-PF drugs. This article reviews the current research progress in roles of key cells and molecules in pathogenesis of PF, so as to provide a reference for the further research and development of anti-PF drugs.
Key words: pulmonary fibrosis, cellular mechanism, molecular target
陈骋 张旋 洪志鹏. 肺纤维化形成中的关键细胞及分子研究进展[J]. 基础医学与临床, 2018, 38(9): 1329-1332.
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