基础医学与临床 ›› 2018, Vol. 38 ›› Issue (1): 107-111.
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牛书俐,庞骁,周莉,李素平
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摘要： 整合素是一个异源二聚体组成的膜受体蛋白家族，能特异性识别精氨酸-甘氨酸-天冬氨酸（RGD）序列。整合素在肿瘤细胞和新生血管高表达。利用它们3者之间特殊关系，将RGD作为载体，与放射性示踪剂、抗肿瘤药物以及其他物质结合，使其具有亲肿瘤显像、靶向抗肿瘤治疗、抗感染、抗抑郁和骨骼及神经修复等作用。
关键词: 精氨酸-甘氨酸-天冬氨酸序列, 整合素, 分子显像, 抗肿瘤, 抗感染
Abstract: The integrin is a family of membrane receptor proteins,which is composed of heterologous dimer,and can identify the sequence RGD.Integrin excessive expressed in tumor cells and angiogenesis.Using their special relationship among them,the RGD as the carrier,combined with the radioactive tracer, antineoplastic drugs and other substances,which has tumoraffin imaging,targeted anticancer therapy,anti-inflammatory,anti depression effect and bone and nerve repair, and so on.
Key words: Arg-Gly-Asp, Integrin, Molecular image, antineoplastic, Anti-inflammatory
中图分类号:
R319
牛书俐 庞骁 周莉 李素平. RGD三肽的临床应用进展[J]. 基础医学与临床, 2018, 38(1): 107-111.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2018/V38/I1/107
