基础医学与临床 ›› 2018, Vol. 38 ›› Issue (1): 103-106.

• 短篇综述 • 上一篇    下一篇

SIRT在肠屏障中作用的研究进展

陈杰,万剑华,吴当彦,夏亮   

  1. 南昌大学第一附属医院
  • 收稿日期:2016-10-31 修回日期:2017-01-17 出版日期:2018-01-05 发布日期:2017-12-26
  • 通讯作者: 夏亮 E-mail:liangx96180@126.com

Research progress on the role of SIRT in intestinal barrier

  • Received:2016-10-31 Revised:2017-01-17 Online:2018-01-05 Published:2017-12-26

摘要: 沉默信息调节子(SIRT)是一组保守的NAD+依赖的蛋白去乙酰化酶,参与调控细胞的基因稳定、代谢、衰老和凋亡等过程。研究表明,SIRT对肠屏障具有保护作用,其通过参与调节炎性因子的释放、肠上皮细胞间紧密连接蛋白的表达、改变肠道潘氏细胞和杯状细胞的数量等影响肠屏障的结构与功能。

关键词: SIRT, 组蛋白去乙酰化酶, 肠屏障

Abstract: SIRT are a family of highly conserved nicotine adenine dinucleotide(NAD+)-dependent protein deacetylase, regulating several processes including cell gene stability, metabolism, aging and apoptosis. Studies have shown that SIRT has protective effects on intestinal barrier, which influences the structure and function of intestinal barrier by controlling the release of inflammatory cytokines, regu-lating the expression of tight junction protein in intestinal epithelial, and changing the number of Paneth and goblet cells in the intestine.

Key words: SIRT, protein deacetylase, intestinal barrier

中图分类号: