基础医学与临床 ›› 2017, Vol. 37 ›› Issue (8): 1157-1160.

• 临床研究 • 上一篇    下一篇

马凡综合征患者行脊柱侧凸矫形手术的围术期血液管理

陈唯韫1,刘子嘉1,虞雪融2,黄宇光3   

  1. 1. 中国医学科学院北京协和医院
    2. 北京协和医院麻醉科
    3. 北京协和医院
  • 收稿日期:2016-11-07 修回日期:2017-03-20 出版日期:2017-08-05 发布日期:2017-07-17
  • 通讯作者: 陈唯韫 E-mail:chenweiyun@pumch.cn

Perioperative blood management of patients with Marfan syndrome undergoing scoliosis surgery

  • Received:2016-11-07 Revised:2017-03-20 Online:2017-08-05 Published:2017-07-17
  • Contact: Wei-Yun CHEN E-mail:chenweiyun@pumch.cn

摘要: 目的 分析马凡综合征(Marfan syndrome, MS)患者行脊柱侧凸矫形手术患者的麻醉及围术期血液管理特点。方法 回顾分析2013年1月至2015年12月在北京协和医院接受脊柱侧凸矫形手术并合并MS患者的临床资料并与非MS患者(对照组)对比,分别统计两组患者的术前一般信息、手术麻醉信息和围术期用血情况等,并作统计学分析。结果 MS组术前合并眼部疾病、超声心动图检查异常和通气功能障碍患者比例显著多于对照组(P<0.05);术中出血量、异体血输血率及量和自体血回输使用率及回输量较对照组显著增加(P<0.05);手术及麻醉时间、术后住院时间显著延长(P<0.05)。结论 MS患者常有多系统受累,合并症多,行脊柱侧凸矫形手术的出血风险大,其围术期麻醉管理应格外谨慎,应加强血液管理,必要时采用有创检测。

关键词: 马凡综合征, 脊柱侧凸矫形手术, 围术期, 麻醉, 血液管理

Abstract: Objective To investigate the anesthesia and perioperative blood management of patients with Marfan syndrome (MS) undergoing scoliosis surgery. Methods The clinical data of MS patients underwent scoliosis surgery from January 2013 to December 2015 in Peking Union Medical College Hospital were collected and compared with patients received the same surgery but without MS. Perioperative information and data on anesthesia and blood management were analyzed. Results Compared with control group, MS patients were found with more preoperative comorbidities with statistical significance, including eye disease, echocardiographic abnormalities, and ventilatory defects. MS patients had significantly more blood loss, more intraoperative and postoperative allogeneic and autologous blood transfusion. The operation time, anesthesia time, and length of postoperative hospital stay were all significantly longer in MS patients. Conclusions MS patients are common with multi-system involvement and comorbidities. Considering the high risk of perioperative bleeding, the anesthesia and blood management for MS patients undergoing scoliosis surgery should be with extra caution. Blood management should be applied and appropriate invasive monitoring methods should be considered when necessary.

Key words: Marfan syndrome, scoliosis surgery, perioperative management, anesthesia, blood management

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