基础医学与临床 ›› 2017, Vol. 37 ›› Issue (5): 705-708.

• 研究论文 • 上一篇    下一篇

CEACAM1和CD34蛋白表达与胃癌侵袭转移的关系

潘棋1,陈艳1,向培1,黄逸姣1,谢楠岚1,章烨2   

  1. 1. 无锡市第二中医医院
    2. 无锡市第四人民医院
  • 收稿日期:2016-11-29 修回日期:2017-02-06 出版日期:2017-05-05 发布日期:2017-04-19
  • 通讯作者: 潘棋 E-mail:panqi7276@163.com

Relationship between the expression of CEACAM1, CD34 and the metastasis of gastric cancer

  • Received:2016-11-29 Revised:2017-02-06 Online:2017-05-05 Published:2017-04-19

摘要: 目的:探讨CEACAM1和CD34蛋白表达与胃癌侵袭、转移的关系。方法:免疫组化SP法检测90例胃癌组织和30名正常胃黏膜组织中CEACAM1及CD34的表达情况,分析CEACAM1和CD34标记的MVD与胃癌患者临床病理特征的关系。结果:CEACAM1和CD34蛋白在胃癌中的阳性表达明显高于正常胃黏膜组织(P<0.05)。CEACAM1蛋白的表达程度与肿瘤分化、侵袭深度、是否淋巴结转移及病理分期相关(P<0.05),胃癌组织中MVD与肿瘤大小、分化、侵袭深度、是否淋巴结转移及病理分期相关(P<0.05)。CEACAM1阳性表达程度及CD34标记的MVD在胃癌中的表达呈正相关关系(P<0.05)。结论:CEACAM1与CD34参与了胃癌的侵袭和转移,有望成为胃癌发生、发展和预后的预测指标。

关键词: 【关键词】 癌胚抗原相关黏附分子1, 微血管密度, 胃癌, 免疫组化

Abstract: Objective To investigate the prognostic impact of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and CD34 on invasion and metastasis of gastric cancer. Methods CEACAM1 and CD34 expressions were detected by immunhistochemistry in 90 cases of gastric cancer and 30 cases of normal gastric mucosa. Then the relationship among CEACAM1, MVD marked by CD34 antibody and gastric cancer patients’ clinical pathological features and prognosis were analyzed. Results The positive rates of CEACAM1 and CD34 protein in gastric cancer were significantly higher than those in normal gastric mucosa (P<0.05). The positive degree of CEACAM1 was closely associated with histological differentiation, tumor invasion, nodal metastasis and TNM stage. MVD marked by CD34 was related with tumor size, histological differentiation, tumor invasion, nodal metastasis and TNM stage(P<0.05). Conclusions In gastric cancer, CEACAM1 and CD34 promote its capability of invasion and metastasis, and they might be used as an indicator in predicting development and prognosis.

Key words: [Key words] carcinoembryonic antigen-related cell adhesion molecule 1, microvessel density, gastric cancer, immunhistochemistry