基础医学与临床 ›› 2017, Vol. 37 ›› Issue (3): 419-421.

• 短篇综述 • 上一篇    下一篇

哮喘气道平滑肌细胞表观遗传学调控的研究进展

吕欣,莫碧文   

  1. 桂林医学院
  • 收稿日期:2016-08-22 修回日期:2016-11-01 出版日期:2017-03-05 发布日期:2017-02-23
  • 通讯作者: 莫碧文 E-mail:lvxinxin250@163.com
  • 基金资助:
    Mir-140b-3p调控CD38/NAADP信号通路参与哮喘气道平滑肌细胞自噬、凋亡的机制研究

Progress in the study of epigenetic regulation of airway smooth muscle cells in asthma

  • Received:2016-08-22 Revised:2016-11-01 Online:2017-03-05 Published:2017-02-23

摘要: 哮喘气道重塑中一个主要方面即是平滑肌细胞的增生肥大,近些年,人们逐渐发现表观遗传学对气道平滑肌细胞的增殖和分泌炎性因子方面有着重要的调节作用,其中包括DNA甲基转移酶抑制剂可以抑制其表型转换;组蛋白乙酰化与其增生肥大相关;另外,Mir-RNA可以调控哮喘模型中气道平滑肌细胞的各种生理功能,包括抑制其增殖及炎性因子的释放。希望表观遗传学能够成为治疗哮喘的新型靶点。

关键词: 支气管哮喘, 气道平滑肌细胞, 表观遗传学

Abstract: Hyperplasia of smooth muscle cells is a major aspect of airway remodeling in asthma.In recent years, people gradually found that the epigeneticsplays an important role on the proliferation of airway smooth muscle cells and the secretion of inflammatory cytokines, including DNA methyltransferase inhibitors to inhibit the phenotype transformation; histone acetylation related with hypertrophy. In addition, the Mir-RNA can be related with the regulation of a variety of physiological functions of airway smooth muscle cells of asthma model, including inhibition of proliferation and release of inflammatory factors. Hope that epigenetics can become a new target for the treatment of asthma.

Key words: Asthma, Airway smooth muscle cell, Epigenetics