基础医学与临床 ›› 2017, Vol. 37 ›› Issue (2): 256-260.

• 短篇综述 • 上一篇    下一篇

电离辐射诱导造血干细胞损伤的分子机制研究进展

方连英,王彦,徐畅,杜利清,王芹,刘强   

  1. 中国医学科学院放射医学研究所
  • 收稿日期:2016-04-19 修回日期:2016-05-29 出版日期:2017-02-05 发布日期:2017-01-16
  • 通讯作者: 刘强 E-mail:liuqiang@irm-cams.ac.cn
  • 基金资助:
    国家自然科学基金资助项目;天津市自然科学基金;天津市自然科学基金;教育部高等学校博士点基金

Research progress in molecular mechanism of hematopoietic stem cell injury induced by ionizing radiation

  • Received:2016-04-19 Revised:2016-05-29 Online:2017-02-05 Published:2017-01-16

摘要: 电离辐射(IR)诱导的造血干细胞(HSC)损伤是IR后引发机体死亡的主要原因,其损伤机理主要涉及p53-Puma通路诱导HSC凋亡;激活G-CSF/Stat3/BATF依赖性的分化检验点促进HSC分化;ROS-p38通路诱导HSC衰老以及损伤HSC龛。近期研究为预防和治疗电离辐射引起的骨髓抑制提供了理论基础。

关键词: 电离辐射,造血干细胞,凋亡,分化,衰老

Abstract: Hematopoietic stem cell (HSC) injury induced by ionizing radiation (IR) is the primary cause of death after exposure to ionizing radiation. The mechanisms of inducing HSC damage include induction of HSC apoptosis via the p53-Puma pathway; promotion of HSC differentiation via the activation of the G-CSF/Stat3/BATF-dependent differentiation checkpoint; induction of HSC senescence via the ROS-p38 pathway; and damage to the HSC niche. Recent researches provide a basis for the prevention and treatment of bone marrow suppression caused by ionizing radiation.

Key words: Ionizing Radiation, Hematopoietic stem cell, Apoptosis, Differentiation, Senescence

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