基础医学与临床 ›› 2016, Vol. 36 ›› Issue (8): 1159-1163.

• 短篇综述 • 上一篇    下一篇

长链非编码RNA与结直肠癌

吴燕1,陈特1,向阳2,张竹君2   

  1. 1. 重庆医科大学附属第一医院
    2. 第三军医大学第一附属医院
  • 收稿日期:2016-04-14 修回日期:2016-05-30 出版日期:2016-08-05 发布日期:2016-07-13
  • 通讯作者: 张竹君 E-mail:13110287605@163.com
  • 基金资助:
    IBP通过激活Rho GTPase促进结直肠癌细胞EMT的分子机制研究

Long non-coding RNA and colorectal cancer

  • Received:2016-04-14 Revised:2016-05-30 Online:2016-08-05 Published:2016-07-13
  • Contact: Zhu-Jun ZHANG E-mail:13110287605@163.com

摘要: 长链非编码RNA(lncRNA)是一类长度大于200nt的非蛋白编码RNA分子,能同时与DNA、RNA和蛋白质分子相互作用,通过转录和转录后调控等多种作用机制在结直肠癌中发挥促癌或抑癌的双重作用。lncRNA表达异常或突变在结直肠癌的发生、发展、侵袭和转移过程中扮演着重要角色,且与患者预后密切相关。lncRNA有望为成为结直肠癌新的诊断和治疗靶点。

关键词: 长链非编码RNA, 结直肠癌

Abstract: Long non-coding RNA (lncRNA, >200 nt)can interact with DNA, RNA, protein molecules and/or their combinations. lncRNA is an essential regulator in transcriptional and post-transcriptional regulation and act as tumor promoter or suppresser in colorectal cancer. Misexpression or mutation of lncRNA play an important role in cancer genesis, development, invasion and metastasis and close related to patient prognosis. Taken together, lncRNA may be an important target for colorectal cancer diagnosis and treatment.

Key words: long non-coding RNA, colorectal cancer

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