基础医学与临床 ›› 2016, Vol. 36 ›› Issue (6): 852-855.

• 短篇综述 • 上一篇    下一篇

DKK3与胃癌的相关性研究进展

宋国栋,牛远杰   

  1. 天津医科大学第二医院
  • 收稿日期:2016-03-30 修回日期:2016-04-20 出版日期:2016-06-05 发布日期:2016-05-27
  • 通讯作者: 牛远杰 E-mail:venussoon1982@aliyun.com
  • 基金资助:
    DKK-3在胃癌中的表达及其甲基化与临床预后的研究

Progress in the study of the relationship between DKK3 and gastric cancer

  • Received:2016-03-30 Revised:2016-04-20 Online:2016-06-05 Published:2016-05-27

摘要: 胃癌的发生是多基因的遗传学与表观遗传学共同作用的结果。DKK3(dickkopf3)是近年来发现的抑癌基因,是经典Wnt信号传导通路的拮抗因子。当DKK3蛋白质失活时,Wnt信号通路异常激活,从而导致肿瘤的发生。DKK3基因表达沉默是胃癌中的频发事件,启动子甲基化为其表达沉默的常见原因,且与胃癌预后不良显著相关。

关键词: Dickkopf-3基因, 胃癌, 抑癌基因, 分子甲基化, 生物标志物

Abstract: The development of gastric cancer is a result of a multi gene genetic and epigenetic common function. DKK3(dickkopf-3) is a newly discovered tumor suppressor gene and an antagonist of the classic Wnt signaling pathway. DKK3 protein inactivation and Wnt signal pathway abnormal activation can lead to tumor occurrence. The silence of DKK3 gene expression is a frequent event of gastric cancer, which was usually caused by the promoter methylation, and significantly correlateswith the prognosis of gastric cancer.