基础医学与临床 ›› 2015, Vol. 35 ›› Issue (6): 830-832.

• 临床园地 • 上一篇    下一篇

7例单纯分泌雄激素的肾上腺皮质腺瘤的临床特征

童安莉1,李乃适2,张巧慧3,李梅4,卢琳5,伍学焱6   

  1. 1. 中国医学科学院北京协和医学院北京协和医院内分泌科 卫生部内分泌重点实验室
    2. 协和医院内分泌科
    3. 山西省运城市中心医院
    4. 中国医学科学院 北京协和医学院 北京协和医院
    5. 中国医学科学院 北京协和医学院 北京协和医院内分泌科 卫生部内分泌重点实验室
    6. 北京协和医院内分泌科
  • 收稿日期:2015-03-20 修回日期:2015-04-15 出版日期:2015-06-05 发布日期:2015-05-27
  • 通讯作者: 伍学焱 E-mail:wsheyan@vip.sina.com

Clinical characteristics of seven cases with pure androgen-producing adrenal adenoma

  • Received:2015-03-20 Revised:2015-04-15 Online:2015-06-05 Published:2015-05-27

摘要: 目的 总结单纯分泌雄激素的肾上腺皮质腺瘤的临床特征。方法 回顾性分析北京协和医院2002~2014年收治的7例单纯分泌雄激素的肾上腺皮质腺瘤患者的临床资料。结果 患者起病年龄3.5~31岁,病程1.5~30年。其中女性6例,具有不同程度的男性化表现;男性1例,表现为性早熟。术前血清总睾酮水平4.1~33.0nmol/L,术后女性患者睾酮均降至正常(0.1~1.3nmol/L),临床症状缓解;7岁的男性患者由于继发了中枢性性早熟,其术后睾酮虽一度下降,但随即又升高(4.1nmmol/L),加用长效GnRHa制剂治疗后控制到青春期前水平。7例患者手术病理均为肾上腺皮质腺瘤。结论 单纯分泌雄激素的肾上腺皮质腺瘤多在儿童期起病;依性别及年龄不同,患者的临床表现各异,容易漏诊。对出现女性男性化、月经紊乱或性早熟的患者应警惕此病的可能。

关键词: 肾上腺皮质腺瘤, 高雄激素血症, 临床特征, 治疗

Abstract: Objective: To study the clinical characteristics of pure androgen-producing adrenal adenoma. Method: Clinical data from 7 cases with pure androgen-producing adrenal adenoma treated in PUMCH from 2002 to 2014 were analyzed retrospectively. Results:Seven patients with age at onset from 3.5 to 31 years had various clinical courses from 1.5 to 30 years. All female patients (n=6) had virilism and one male patient developed sexual precocity. Serum testosterone levels were 4.1-33.0 nmol/L preoperatively and in the females decreased to 0.1-1.3nmol/L postoperatively accompanying with relief of the symptoms, and decreased to 4.1mmol/L for the boy because of secondary central precocious puberty. All the tumors were histologically diagnosed with adrenocortical adenoma. Conclusions: Pure androgen-producing adrenal adenoma usually occurs in childhood. Clinical characteristics are various according to the sex and age of the patients. Androgen-producing adrenal adenoma should be suspected when the patients develop virilism, menstrual disorder, or sexual precocity.

Key words: Adrenal adenoma, Hyperandrogenemia, Clinical characteristics, Treatment

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