基础医学与临床 ›› 2015, Vol. 35 ›› Issue (6): 802-806.

• 研究论文 • 上一篇    下一篇

Trop-2在结直肠癌组织中的表达及其意义

乔宇,赵鹏,陈适,刘春辉,张国志   

  1. 河北联合大学附属医院
  • 收稿日期:2014-12-16 修回日期:2015-01-23 出版日期:2015-06-05 发布日期:2015-05-27
  • 通讯作者: 张国志 E-mail:272362887@qq.com

Expression and significance of Trop-2 in colorectal cancer

  • Received:2014-12-16 Revised:2015-01-23 Online:2015-06-05 Published:2015-05-27

摘要: 目的 探讨人滋养层细胞表面抗原-2(Trop-2)在结直肠癌中的表达及其意义。方法 用免疫组化法检测84例结直肠癌组织标本及其相对应的癌旁正常组织中的Trop-2表达情况,分析其表达与临床病理特点的关系,进一步采用Western blot检测34例手术标本的Trop-2表达情况。结果 Trop-2在结直肠癌组织中的表达高于癌旁正常组织(P<0.05);Trop-2表达量:直肠癌(RC)组﹥左半结肠癌(LSCC)组﹥右半结肠癌(RSCC)组(P<0.05),Dukes’ C+D组﹥A+B组(P<0.05),淋巴结转移组﹥无淋巴结转移组(P<0.05),远处转移组﹥无远处转移组(P<0.05);与性别、年龄、分化程度无关。结论 Trop-2在结直肠癌组织中高表达,与Dukes分期、淋巴结转移、远处转移和肿瘤所在部位有关。

关键词: 结直肠癌, Trop-2

Abstract: Objective To explore the trophoblast cell surface antigens 2 (Trop-2) expression and significance in colorectal cancer. Methods Trop-2 expressions were detected with immunohistochemistry in 84 colorectal cancer tissue samples and corresponding tumor-adjacent normal tissues. We analyzed the relationship between Trop-2 expression and clinic pathological features of colorectal cancer. We also detected 34 surgical removal of the specimen with western blot to analyze the Trop-2 expression of colorectal cancer. Results Trop-2 expression was higher in colorectal cancer tissue samples than that in corresponding tumor-adjacent normal tissues (P<0.05). Trop-2 expression was higher in rectal cancer than that in left-sided and right-sided colon cancer (P<0.05). Colorectal cancer with higher Dukes’ stage or lymph node metastasis and distant metastasis, the Trop-2 expression is higher than that in corresponding tissues (P<0.05). The study found no significance in age, gender and degrees of differentiation. Conclusion Trop-2 was highly expressed in colorectal cancer, which was closely related to Dukes’ stage, lymph node metastasis, distant metastasis and the tumor site.

Key words: colorectal cancer, Trop-2

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