基础医学与临床 ›› 2015, Vol. 35 ›› Issue (3): 413-416.

• 短篇综述 • 上一篇    下一篇

脑缺血再灌注中一氧化氮对神经元凋亡的影响

边经纬1,李俊发1,罗艳琳2   

  1. 1. 首都医科大学
    2. 首都医科大学神经生物学系 北京神经科学研究所
  • 收稿日期:2014-07-30 修回日期:2014-11-28 出版日期:2015-03-05 发布日期:2015-03-03
  • 通讯作者: 罗艳琳 E-mail:luoyl@ccmu.edu.cn
  • 基金资助:
    首都医科大学基础临床合作课题,首都医科大学科研基金课题

The effect of nitric oxide on neuronal apoptosis during cerebral ischemia-reperfusion

  • Received:2014-07-30 Revised:2014-11-28 Online:2015-03-05 Published:2015-03-03

摘要: 脑缺血再灌注过程中, 脑组织一氧化氮(NO)含量呈“双峰样”变化。作用也随其在机体内含量变化具有不同表现;NO主要通过4条信号通路影响细胞凋亡。NO可通过分子修饰使相关蛋白发生s-亚硝基化,调节信号通路,进而影响细胞凋亡。

关键词: 一氧化氮, 细胞凋亡, 脑缺血再灌注, 信号通路, s-亚硝基化

Abstract: Nitric oxide level of cerebral tissue was "double peaks-like" during cerebral ischemia-reperfusion, and the role of nitric oxide will change depending on its level in vivo. Nitric oxide mediated apoptosis mainly through four signal pathways. Nitric oxide can make related protein s-nitrosylation via molecular modification, further regulate signal pathways and affect apoptosis.

Key words: Nitric oxide, Apoptosis, Cerebral ischemia-reperfusion, Signal pathway, S-nitrosylation