基础医学与临床 ›› 2014, Vol. 34 ›› Issue (9): 1301-1304.

• 短篇综述 • 上一篇    下一篇

幽门螺杆菌感染、P16基因甲基化与胃癌

王犇1,吕志发1,谢勇2   

  1. 1. 南昌大学第一附属医院消化内科
    2. 南昌大学第一附属医院消化系疾病研究所
  • 收稿日期:2013-12-26 修回日期:2014-03-22 出版日期:2014-09-05 发布日期:2014-09-02
  • 通讯作者: 谢勇 E-mail:xieyong_med@163.com

Helicobacter pylori infection,P16 methylation and gastric cancer

  • Received:2013-12-26 Revised:2014-03-22 Online:2014-09-05 Published:2014-09-02

摘要: P16基因是细胞周期负调控基因, 其甲基化与胃癌的发生有关。幽门螺杆菌感染是胃癌主要危险因素之一。幽门螺杆菌感染与P16基因的甲基化有关,使P16表达缺失,从而促使胃癌发生发展。

关键词: 幽门螺杆菌, p16基因, DNA甲基化, 胃癌

Abstract: P16 (CDKN2A/MTS1) gene is a cell cycle regulator involved in the inhibition of G1 phase progression and P16 methylation is associated with the progression of gastric cancer. Helicobacter pylori infection is one of the most important risk factors for gastric cancer. H. pylori infection could potently induce methylation of P16 CpG island. The inactivation of P16 by methylation of CpG islands could cause gastric cancer.

Key words: helicobacter pylori, P16 gene, DNA methylation, gastric cancer

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