基础医学与临床 ›› 2014, Vol. 34 ›› Issue (9): 1289-1292.

• 短篇综述 • 上一篇    下一篇

基因治疗与眼部纤维化疾病

陈向武1,赵颖熙2   

  1. 1. 浙江大学医学院附属义乌医院
    2. 浙江大学 医学院 附属义乌医院
  • 收稿日期:2013-12-26 修回日期:2014-03-24 出版日期:2014-09-05 发布日期:2014-09-02
  • 通讯作者: 陈向武 E-mail:44526789@qq.com

Gene therapy and ocular fibrotic disorders

  • Received:2013-12-26 Revised:2014-03-24 Online:2014-09-05 Published:2014-09-02

摘要: 眼球是最适合进行基因治疗的器官之一。随着转化生长因子-β信号通路的认识及miRNA、RNAi等技术的进步,使得基因治疗在眼部纤维性疾病的应用中更具潜力。目前多种眼部纤维化疾病的基因治疗研究进展迅速,但仍面临较多亟待解决的问题。

关键词: 基因治疗, 眼部纤维化疾病, 转化生长因子-β, 微RNA, RNA干扰

Abstract: Eye is one of the most suitable organs for gene therapy. With the understanding of TGF-β signaling pathway and progressing in the technology of miRNA and RNAi,Gene therapy is more promising in curing ocular fibrotic disorders. Although the gene therapy research in kinds of eye fibrotic diseases is developing rapidly, many problems need to be solved.

Key words: Gene therapy, ocular fibrotic disorders, Transforming growth factor beta, MicroRNA, RNA Interference