基础医学与临床 ›› 2014, Vol. 34 ›› Issue (9): 1285-1288.

• 短篇综述 • 上一篇    下一篇

脂联素及基因多态性与非酒精性脂肪肝的研究进展

叶瑶1,于健2   

  1. 1. 桂林医学院
    2. 桂林医学院附属医院
  • 收稿日期:2014-01-06 修回日期:2014-03-23 出版日期:2014-09-05 发布日期:2014-09-02
  • 通讯作者: 于健 E-mail:duduyu1623@qq.com
  • 基金资助:
    广西壮族自治区卫生厅科研课题

Adiponectin level and its gene polymorphisms and nonalcoholic fatty liver disease

  • Received:2014-01-06 Revised:2014-03-23 Online:2014-09-05 Published:2014-09-02

摘要: 脂联素(APN)作为一种新发现的由脂肪细胞特异性分泌的激素,具有广泛生物学效应,可通过影响肝脏脂肪代谢、炎症因子产生和胰岛素敏感性等,抑制非酒精性脂肪肝(NAFLD)的形成与进展。人脂联素基因启动子区存在相当数量的等位基因单核苷酸多态性(SNPs),而脂联素基因SNPs部分位点与NAFLD发病密切相关,这可能为NAFLD的防治提供了新的途径和方法。

关键词: 脂联素, 单核苷酸多态性, 非酒精性脂肪肝

Abstract: Adiponectin(APN) is a newly discovered adipocytes-secreted protein having extensive biologic effect in anti-inflammatory and the regulation of lipid metabolism and insulin sensitivity, which may inhibit the development of nonalcoholic fatty liver disease. A large number of alleles single nucleotide polymorphisms (SNPs) appear in promoter region of adiponectin gene sequence of human. And part of SNPs are positively correlated with NAFLD, which are likely to provide a new means for the early diagnosis and therapy of NAFLD.

Key words: adiponectin, single nucleotide polymorphisms, nonalcoholic fatty liver disease