基础医学与临床 ›› 2013, Vol. 33 ›› Issue (9): 1195-1198.

• 研究论文 • 上一篇    下一篇

闭环自反馈系统输注罗库溴铵在肝脏手术中的应用

宋锴澄1,卢欣1,易杰2   

  1. 1. 北京协和医院
    2. 中国医学科学院北京协和医学院北京协和医院麻醉科
  • 收稿日期:2013-06-25 修回日期:2013-07-05 出版日期:2013-09-05 发布日期:2013-08-28
  • 通讯作者: 易杰 E-mail:easyue@163.com

Continuous infusion of rocuronium with close-loop auto-feedback system in hepatic surgery

  • Received:2013-06-25 Revised:2013-07-05 Online:2013-09-05 Published:2013-08-28

摘要: 目的 研究闭环自反馈系统持续输注罗库溴铵维持开腹肝脏手术肌松可行性和临床效果。方法 肝脏手术患者30例(ASA I/II),随机分为罗库溴铵闭环自动持续输注组(A 组15例)和手动间断推注组(B组15例),在肌松监测下记录患者的恢复指数、拮抗时间、恢复时间和罗库溴铵平均用量并分析其相关性。记录外科医生满意度。结果 两组患者的罗库溴铵恢复指数没有差异,A组拮抗时间和恢复时间短于B组(P<0.01),且与罗库溴铵平均用量有显著相关性(P<0.01)。两组患者均没有出现呼吸系统并发症或其他不良事件。B组的外科满意度更高(P<0.01)。结论 肝脏手术中利用闭环自动反馈系统持续输注罗库溴铵安全可行,可减少肌松药用量,降低肌松药残余作用风险。

关键词: 罗库溴铵, 闭环自反馈系统, 肝脏手术

Abstract: Objective To assess the clinical effect of continuous infusion of rocuronium with close-loop auto-feedback system on laparotomic hepatic surgery. Methods 30 patients (ASA I/II) who underwent hepatic surgery were randomized divided into continuous infusion of rocuronium group (group A, n=15) and intermittent bolus infusion group (group B, n=15). Recovery index, antagonistic time, recovery time and the average amount of rocuronium were compared between the two groups under muscle relaxants monitoring. Surgeons’ satisfactory scores were recorded. Results There was no significant difference inrecovery index between the two groups (P = 0.59> 0.05), while antagonistic and recovery time of group A wereshorter than those of group B (P <0.01), and both correlated with rocuronium average amount (at 0.01 level).Patients in both groups did not appear any respiratory complications or any other adverse events after extubation. Group B had higher satisfactory scores from surgeons (P <0.01). Conclusion Continuous infusion of rocuronium with close-loop auto-feedback system in hepatic surgery was safe. It reduced rocuroium’s amount, and could reduce the risks of residual neuromuscular blockade.

Key words: rocuronium, close-loop feedback system, hepatic surgery

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