基础医学与临床 ›› 2013, Vol. 33 ›› Issue (7): 927-930.

• 短篇综述 • 上一篇    下一篇

登革病毒样颗粒疫苗的研究现状

付春云1,戴盛明1,周俊梅2   

  1. 1. 广西医科大学第四附属医院
    2. 中山大学中山医学院
  • 收稿日期:2012-06-15 修回日期:2012-09-25 出版日期:2013-07-05 发布日期:2013-06-26
  • 通讯作者: 周俊梅 E-mail:junmeizh@126.com

Review of study on Dengue virus-like particles vaccine

  • Received:2012-06-15 Revised:2012-09-25 Online:2013-07-05 Published:2013-06-26

摘要: 登革病毒引起的疾病是一种严重威胁人类健康的蚊媒性急性传染病。但至今仍没有获批准的疫苗可用。近年,一种新的病毒样颗粒(VLPs)能使免疫小鼠产生中和性抗体和持久、特异的T淋巴免疫记忆细胞。VLPs克服了传统疫苗的很多不足,具有较大应用潜力。

关键词: 登革病毒, 病毒样颗粒, 疫苗, 蚊媒性传染病

Abstract: The disease caused by Dengue virus is an acute life-threatening mosquito-borne infectious disease. So far, an effective and safe vaccine for dengue is not yet available. Recently a new virus-like particles vaccine can be capable of inducing the vaccinated mice to produce neutralizing antibody, and long-lasting virus-specific memory T lymphocytes. What more, it also can be widely explored by using yeast expression system. Its special priorities make it become a hopeful ideal dengue vaccine.

Key words: dengue virus, virus-like particles, vaccine, mosquito-borne infectious disease