基础医学与临床 ›› 2013, Vol. 33 ›› Issue (1): 9-14.
• 最新分子细胞生物学技术专题 • 上一篇 下一篇
周珏宇,石嵘,郑文岭,马文丽
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摘要： 研究发现，某些miRNAs与细胞周期调控有关，它们可以通过靶向E2F、Cdks、cyclins、CKI等促进或阻滞细胞周期的关键调节因子，进而调控细胞周期，并且这种由miRNAs介导的细胞周期调控方式与恶性肿瘤的发生发展密切相关。本综述主要介绍miRNA与肿瘤细胞周期的关系及其研究策略。
Abstract: Recent studies have identi?ed speci?c microRNAs that regulate classic cell-cycle control pathways by directly targeting proteins such as E2F transcription factors, cyclin-dependent kinases (Cdks), cyclins and Cdk inhibitors, and have documented that the loss or gain of miRNA-mediated cell-cycle control contributes to malignancy. This review summarizes experimental strategies for miRNAs research and recent progression on the involvement of miRNAs in cell cycle regulation and tumorigenesis.
周珏宇 石嵘 郑文岭 马文丽. microRNA与肿瘤细胞周期的关系及其研究方法进展[J]. 基础医学与临床, 2013, 33(1): 9-14.
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