基础医学与临床 ›› 2013, Vol. 33 ›› Issue (1): 123-125.

• 短篇综述 • 上一篇    下一篇

EIF5A2在肿瘤中的作用研究进展

孟庆彬1,于健春2,马志强1   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院
    2. 中国医学科学院北京协和医学院北京协和医院普通外科
  • 收稿日期:2012-03-29 修回日期:2012-05-03 出版日期:2013-01-05 发布日期:2012-12-25
  • 通讯作者: 于健春 E-mail:yu-jch@163.com
  • 基金资助:
    中国医学科学院北京协和医学院研究生创新基金

The progress of studies on the role of EIF5A2 in human cancer

  • Received:2012-03-29 Revised:2012-05-03 Online:2013-01-05 Published:2012-12-25
  • Contact: Jian-chun YU E-mail:yu-jch@163.com
  • Supported by:
    the Innovation Funding from Chinese Academy of Medical Science and Peking Union Medical College

摘要: 真核细胞翻译起始因子5A2(EIF5A2)是EIF5A家族中高度进化保守的基因之一。EIF5A2作为可能的癌基因在多种人类上皮源性肿瘤内呈高表达,并与肿瘤的分期和/或预后不佳相关。EIF5A2通过多种机制诱导肿瘤发生上皮间质转化进而促进肿瘤侵袭转移。EIF5A-MTA1/c-MYC轴可能是上皮源性肿瘤发生侵袭转移的重要调控通路之一。相关分子机制尚需进一步研究。

关键词: EIF5A2, 肿瘤, 转移

Abstract: Eukaryotic initiation factor 5A2 gene is a highly conserved gene of EIF5A family. EIF5A2, as a potential oncogene, was highly expressed in a variety of human tumors, and associated with the staging and / or poor prognosis of the tumor. EIF5A2 induces epithelial mesenchymal transition through a variety of the mechanisms, and thus promote tumor invasion and metastasis. EIF5A-MTA1/c-MYC axis may be one of the important pathways involved in regulation of tumor invasion and metastasis. The underlying molecular mechanisms need further studies.

Key words: EIF5A2, cancer, metastasis

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