基础医学与临床 ›› 2011, Vol. 31 ›› Issue (11): 1289-1292.

• 短篇综述 • 上一篇    下一篇

X-盒结合蛋白1的生理及病理生理学作用

张霞丽   

  1. 南昌大学医学院
  • 收稿日期:2010-08-27 修回日期:2010-11-27 出版日期:2011-11-05 发布日期:2011-11-02
  • 通讯作者: 张霞丽 E-mail:381609018@qq.com

Research on Physiological and Pathophysiological Functions of X- box Binding Protein

张霞丽 ZHANG Xia-Li   

  • Received:2010-08-27 Revised:2010-11-27 Online:2011-11-05 Published:2011-11-02
  • Contact: 张霞丽 ZHANG Xia-Li E-mail:381609018@qq.com

摘要: X-盒结合蛋白1(X- box binding protein,XBP-1)是未折叠蛋白反应的重要组分,有剪接型XBP-1(XBP-1S)和非剪接型XBP-1(XBP-1U) 两种形式,前者活性远远高于后者。当细胞处于内质网应激状态时,XBP-1由ATF6诱导,经IRE1非传统剪接,转录有功能的XBP-1S,活化未折叠蛋白反应。XBP-1是一种重要的转录因子,对细胞生长和分化具有重要调控作用,并与人类多种疾病的发生和发展相关。

关键词: X-盒结合蛋白1, 转录调控, 内质网应激, 疾病

Abstract: ABSTRACT:X-box binding protein 1 is an important component of unfolded protein response.XBP-1 has two splicing variants that were designated XBP-1S and XBP-1U. The former activity is much higher than the latter. When the cell is on the condition of endoplasmic reticulum stress, XBP-1 is induced by ATF6,and spliced by IRE1,then the functional XBP-1S was transcripted, and activation of unfolded protein response. XBP-1 is an important transcription factor,it has an important regulatory role on cell growth and differentiation.XBP-1 is involved in the genesis,development of many diseases.

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