关键词: 食管鳞癌, hOGG1, 8-oxoG, 凋亡

Abstract: Objective The relationship between the expression of HOGG1 in esophageal squamous cell carcinoma (ESCC) tissues and its 8-oxoG oxidative damage, its clinical and pathologic characteristic was investigated. Methods The expression of HOGG1 protein and the 8-oxoG oxidative damage between ESCC tissues and the adjacent tissues were compared by immunohistochemistry and western blot. And TUNEL kit was used to detect the apoptosis index (AI) of these tissues. The results showed that there were differences of HOGG1 expression among ECSS patients, and the different level of HOGG1 expression in ECSS tissues and the adjacent tissues. Results Decreased HOGG1 expression and increased 8-oxoG oxidative damage of ESCC tissues were found, compared with the adjacent tissues （P＜0.05）. Decreased HOGG1 expression of ESCC tissues was associated negatively with their 8-oxoG oxidative damage and AI, and associated with carcinoma vein encroachment and lymph node metastasis, but not associated with patients’ gender, age, pathological differentiation grade. Conclusion Postoperative routine detection of HOGG1 expression with the patients’ ESCC tissues may be useful for the guidance of making the patients’ chemotherapeutic schedule.