基础医学与临床 ›› 2010, Vol. 30 ›› Issue (9): 925-929.

• 研究论文 • 上一篇    下一篇

鸢尾苷对高脂血症大鼠血清脂质的影响

王金凤 杨翠燕 张艳萍 侯明晓 王芳 王国玉 王淑红   

  1. 中国人民解放军第二O八医院
  • 收稿日期:2009-10-10 修回日期:2009-12-23 出版日期:2010-09-05 发布日期:2010-09-05
  • 通讯作者: 王金凤

Effect of Tectoridin on Serum Lipid in Rat Model with hyperlipidemia

Jin-feng WANG, Cui-yan YANG, Yan-ping ZHANG, Ming-xiao HOU, Fang WANG, Guo-yu WANG, Shu-hong WANG   

  1. the 208th Hospital of the Chinese People′s Liberation Army
  • Received:2009-10-10 Revised:2009-12-23 Online:2010-09-05 Published:2010-09-05
  • Contact: Jin-feng WANG,

摘要: 目的 探讨鸢尾苷对高脂血症大鼠血脂水平的影响及其作用机制。方法健康雄性Wistar大鼠48只,随机分为四组,高脂模型组、鸢尾苷大、小剂量组和阿托伐他汀阳性对照组。均以高脂饲料喂养2周后开始灌胃给药,12周后测定血脂水平,采用免疫组化和RT-PCR方法检测肝脏低密度脂蛋白受体(LDL-R)及其mRNA的表达。结果 鸢尾苷具有明显的降血脂作用,尤其是对总胆固醇和低密度脂蛋白的作用明显,而且上调肝脏LDL-R及其mRNA的表达。结论 鸢尾苷具有良好的降脂作用,可能与其显著增强高脂血症大鼠肝脏LDL-R的表达有关。

关键词: 鸢尾苷, 高脂血症, 胆固醇, 低密度脂蛋白受体

Abstract: Objective To investigate the effect of Tectoridin on the lipoprotein of the rat with hyperlipidemia and it?s mechanism. Method 48 healthy male Wistar rats were devided randomly into four groups, high fat diet model group; high doge Tectoridin group; low doge Tectoridin group and Atorvastin group. Each rat was given drugs with intragastric administration after fed with high fat forage for 2 weeks. All the rats blood lipid was mensurated after 12 weeks. LDL-R and it?s mRNA expression in rats? liver were determined by immunohistochemical and RT-PCR method. Result Tectoridin markedly reduced the rat serum lipid and raised the LDL-R and it?s mRNA expression in rats? liver, especially to total cholesterol and low density lipoprotein-cholesterol. Conclusion Tectoridin had significant effect on reducing the rat?s serum lipid perhaps because of increasing the expression of LDL-R in liver of the rat with hyperlipidemia.

Key words: Tectoridin, haperlipidemia, cholesterol, Receptor of low density lipoprotein-cholesterol