基础医学与临床 ›› 2010, Vol. 30 ›› Issue (7): 775-777.

• 短篇综述 • 上一篇    下一篇

心肌细胞凋亡信号传导通路与心肌损伤

戴日新 李浪   

  1. 广西医科大学第一附属医院 广西医科大学第一附属医院
  • 收稿日期:2009-10-09 修回日期:2010-02-14 出版日期:2010-07-05 发布日期:2010-07-05
  • 通讯作者: 李浪

Myocytes apoptosis signal transduction and the myocardium injury

Ri-xin DAI, Lang LI   

  1. The First Affiliated Hospital of Guangxi Medical University The First Affiliated Hospital of Guangxi Medical University
  • Received:2009-10-09 Revised:2010-02-14 Online:2010-07-05 Published:2010-07-05
  • Contact: Lang LI

摘要: 在心肌损伤中,心肌细胞凋亡信号通路包括了依赖于CASPASE的信号途径和不依赖于CASPASE的信号途径,以及炎症、氧化及自噬等信号机制的交联和激活信号途径,心肌细胞的凋亡信号通路决定着心肌的生存与死亡,对心肌损伤的发生和发展及预后产生重要影响。

关键词: 信号传导通路, 凋亡, 心肌细胞

Abstract: The cardiac myocyte apoptosis signal transduction are major include caspase-dependend pathways and caspase-independend pathway ,and also involve crosstalk or interaction with the inflammation、oxidation stress、autophagy and other mechanisms signal networks in myocardium injury. The apoptotic signaling pathway determine the live or death of cardiac myocyte in the heart. It has a great influence on the development and prognosis of the myocardium injury.

Key words: signal transduction, apoptosis, myocytes