铁超载在肝脏疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2023.06.0990

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (6): 990-993.doi: 10.16352/j.issn.1001-6325.2023.06.0990

铁超载在肝脏疾病中的研究进展

刘磊, 丁兰, 袁媛, 叶菁^*

空军军医大学基础医学院病理学教研室,陕西西安 710032

收稿日期:2022-02-25 修回日期:2022-07-21 出版日期:2023-06-05 发布日期:2023-05-31
通讯作者: ^*yejing@fmmu.edu.cn
基金资助:
国家自然科学基金(82170589);陕西省自然科学基础研究计划(2022JM-536)

Advance on iron overload in liver diseases

LIU Lei, DING Lan, YUAN Yuan, YE Jing^*

Department of Pathology, College of Basic Medicinee, Air Force Medical University, Xi'an 710032, China

Received:2022-02-25 Revised:2022-07-21 Online:2023-06-05 Published:2023-05-31
Contact: ^*yejing@fmmu.edu.cn

摘要/Abstract

摘要： 铁是生物体必需的微量元素,含铁蛋白质在细胞功能中起关键作用。铁超载可通过电子传递产生活性氧,引起DNA损伤、氧化应激,造成机体代谢紊乱、组织器官功能障碍。肝脏是机体铁存储的主要脏器,可调节铁的代谢、利用和排出,维持机体铁稳态平衡,铁超载与肝脏疾病的发生发展密切相关。

关键词: 铁超载, 铁代谢, 肝脏疾病, 机制研究

Abstract: Iron is essential for living organisms. Iron-containing proteins play a key role in cell function, while iron overload produces reactive oxygen species through electron transfer, resulting in DNA damage, oxidative stress, metabolic disorder and tissue as well as organ dysfunction. Liver is the main organ of iron storage and is related to regulating the metabolism, utilization and excretion of iron and maintaining iron homeostasis. Iron overload is common in patients with liver diseases, which is closely related to the occurrence and development of liver diseases.

Key words: iron overload, iron metabolism, liver disease, mechanism research

中图分类号:

R363

刘磊, 丁兰, 袁媛, 叶菁. 铁超载在肝脏疾病中的研究进展[J]. 基础医学与临床, 2023, 43(6): 990-993.

LIU Lei, DING Lan, YUAN Yuan, YE Jing. Advance on iron overload in liver diseases[J]. Basic & Clinical Medicine, 2023, 43(6): 990-993.

参考文献 25

[1]	Mori M, Izawa T, Inai Y, et al. Dietary iron overload differentially modulates chemically-induced liver injury in rats[J]. Nutrients, 2020, 12:2784-2798.
[2]	Handa P, Morgan-Stevenson V, Maliken B, et al. Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice[J]. Am J Physiol Gastrointest Liver Physiol, 2016, 310:G117-G127.
[3]	Jo H, Yang J, Park J, et al. Endoplasmic reticulum stress increases DUSP5 expression via PERK-CHOP pathway, leading to hepatocyte death[J]. Int J Mol Sci, 2019, 20:4369-4380.
[4]	Chen C, Wu H, Ye H, et al. Activation of the unfolded protein response (UPR) is associated with cholangio-cellular injury, fibrosis and carcinogenesis in an experimental model of fibropolycystic liver disease[J]. Cancers, 2021, 14:78-99.
[5]	Wang Z, Li M, Liu Y, et al. Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response-induced upregulation of CHAC1 expression[J]. Oncol Rep, 2021, 46:240-253.
[6]	李丹婷, 刘露路, 高茹菲, 等. 内质网应激参与双酚a导致小鼠的肝脏脂质沉积[J]. 基础医学与临床, 2016, 36:886-890.
[7]	Liu H, Lai W, Liu X, et al. Exposure to copper oxide nanoparticles triggers oxidative stress and endoplasmic reticulum(ER)-stress induced toxicology and apoptosis in male rat liver and brl-3a cell[J]. J Hazard Mater, 2021, 401:123349-123360.
[8]	Wu Z, Wang H, Fang S, et al. Roles of endoplasmic reticulum stress and autophagy on H2O2-induced oxidative stress injury in HepG2 cells[J]. Mol Med Rep, 2018, 18:4163-4174.
[9]	Wu A, Feng B, Yu J, et al. Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis[J]. Redox Biol, 2021, 46:102131-102142.
[10]	Protchenko O, Baratz E, Jadhav S, et al. Iron chaperone Poly rC binding protein 1 protects mouse liver from lipid peroxidation and steatosis[J]. Hepatology, 2021, 73:1176-1193.
[11]	Jahng J, Alsaadi R, Palanivel R, et al. Iron overload inhibits late stage autophagic flux leading to insulin resistance[J]. EMBO Rep, 2019, 20:7911-7928.
[12]	Maras J, Das S, Sharma S, et al. Iron-overload triggers ADAM-17 mediated inflammation in severe alcoholic hepatitis[J]. Sci Rep, 2018, 8:10264-10277.
[13]	Tang Y, Wang D, Niu X, et al. Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation[J]. Free Radical Bio Med, 2020, 161:187-197.
[14]	Alajeel N, Shehab M, Francis I, et al. A rare cause of chronic liver disease diagnosed by endoscopic ultrasound-guided liver biopsy[J]. Am J Case Rep, 2021,22:e933002.doi:10.12659/AJCR:933002.doi:10.3389/fmolb.2020.00007.
[15]	Maffei L, Sorrentino F, Caprari P, et al. HCV infection in thalassemia syndromes and hemoglobinopathies: new perspectives[J]. Front Mol Biosci, 2020, 7:7.doi:10.3389/fmolb.2020.00007.
[16]	Kühn J, Meffert P, Heske C, et al. Prevalence of fatty liver disease and hepatic iron overload in a northeastern German population by using quantitative MR imaging[J]. Radiology, 2017, 284:706-716.
[17]	Buzzetti E, Petta S, Manuguerra R, et al. Evaluating the association of serum ferritin and hepatic iron with disease severity in non-alcoholic fatty liver disease[J]. Liver Int, 2019, 39:1325-1334.
[18]	Eder S, Feldman A, Strebinger G, et al. Mesenchymal iron deposition is associated with adverse long-term outcome in non-alcoholic fatty liver disease[J]. Liver Int, 2020, 40:1872-1882.
[19]	Handa P, Thomas S, Morgan-Stevenson V, et al. Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis[J]. J Leukoc Biol, 2019, 105:1015-1026.
[20]	Corradini E, Buzzetti E, Dongiovanni P, et al. Ceruloplasmin gene variants are associated with hyperferritinemia and increased liver iron in patients with NAFLD[J]. J Hepatol, 2021, 75:506-513.
[21]	Zhu M, Chen H, Zhou S, et al. Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload[J]. Nanotoxicology, 2021, 15:761-778.
[22]	Muto Y, Moroishi T, Ichihara K, et al. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis[J]. J Exp Med, 2019, 216:950-965.
[23]	de Campos WN, Massaro J, Cançado E, et al. Comprehensive analysis of HFE gene in hereditary hemochro-matosis and in diseases associated with acquired iron overload[J]. World J Hepatol, 2019, 11:186-198.
[24]	Chung J, Shin E, Kim H, et al. Hepatic iron overload in the portal tract predicts poor survival in hepatocellular carcinoma after curative resection[J]. Liver Int, 2018, 38:903-914.
[25]	Gao R, Kalathur R, Coto-Llerena M, et al. YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis[J]. EMBO Mol Med, 2021, 13:e14351.doi:10.15252/emmm.202114351.

铁超载在肝脏疾病中的研究进展

Advance on iron overload in liver diseases

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