二肽基肽酶Ⅲ在治疗脓毒症中的应用进展

doi:10.16352/j.issn.1001-6325.2023.01.0196

摘要/Abstract

摘要： 脓毒症仍为21世纪医学的重要挑战之一。二肽基肽酶Ⅲ(DPP3)是新发现的与脓毒症相关的生物标志物,在人体内主要降解血管紧张素Ⅱ(Ang Ⅱ),它不仅可以抑制心脏的收缩功能,而且还能够降低血管张力,从而引起心输出量不足、血压降低,导致脓毒症患者发生休克和多器官功能损害。因此DPP3或将成为脓毒症治疗的新靶点。

关键词: 脓毒症, 脓毒性休克, 二肽基肽酶Ⅲ(DPP3), 心力衰竭

Abstract: Sepsis is still one of the important challenges of medicine in the 21st century. Dipeptide peptidase Ⅲ(DPP3)is a new biomarker associated with sepsis, which mainly degrades angiotensin Ⅱ in human body. It can not only inhibit cardiac systolic function, but also reduce vascular tension, resulting in insufficient cardiac output and low blood pressure, resulting in shock and multiple organ dysfunctions in patients with sepsis. Therefore, DPP3 may become a new target for sepsis treatment.

Key words: sepsis, septic shock, dipeptidyl peptidase Ⅲ(DPP3), heart failure

中图分类号:

R459.7

王英臣, 孙立群. 二肽基肽酶Ⅲ在治疗脓毒症中的应用进展[J]. 基础医学与临床, 2023, 43(1): 196-199.

WANG Yingchen, SUN Liqun. Progress on application of dipeptidyl peptidase Ⅲ in the treatment of sepsis[J]. Basic & Clinical Medicine, 2023, 43(1): 196-199.

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