肠道菌群在神经病理性疼痛中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.01.0188

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (1): 188-191.doi: 10.16352/j.issn.1001-6325.2023.01.0188

肠道菌群在神经病理性疼痛中作用的研究进展

吕彦函, 余卓颖^*, 李民^*

北京大学第三医院麻醉科,北京 100191

收稿日期:2021-11-08 修回日期:2022-05-07 发布日期:2022-12-27
通讯作者: ^*liminanesth@bjmu.edu.cn; zhuoyingyu@bjmu.edu.cn
基金资助:
国家自然科学基金(82071411); 国家自然科学基金青年科学基金(82001329)

Research progress of gut microbiota in neuropathic pain

LYU Yanhan, YU Zhuoying^*, LI Min^*

Department of Anesthesiology, Peking University Third Hospital, Beijing 100191,China

Received:2021-11-08 Revised:2022-05-07 Published:2022-12-27
Contact: ^*liminanesth@bjmu.edu.cn; zhuoyingyu@bjmu.edu.cn

摘要/Abstract

摘要： 导致神经病理性疼痛(NP)的作用机制极其复杂。肠道菌群在诱发NP方面起着重要作用。肠道菌群及其代谢产物的改变可通过Toll 样受体(TLRs)促进免疫细胞和神经胶质细胞释放促炎因子,活化免疫系统及炎性反应,这可能是未来治疗NP的潜在靶点。

关键词: 肠道菌群, 神经病理性疼痛, Toll样受体

Abstract: The mechanism of neuropathic pain (NP) is extremely complicated, and current pharmacological treatments for NP are still unsatisfactory. The gut microbiota plays important roles in inducing NP. The changes of gut microbiota and gut microbiota-dependent metabolite could promote the immune cells and glial cells releasing pro-inflammatory cytokines, initiating the innate immune response and inflammation by activating Toll-like receptors (TLRs), which is believed to be a potential candidate to alleviate NP.

Key words: gut microbiota, neuropathic pain, Toll-like receptors

中图分类号:

R363

吕彦函, 余卓颖, 李民. 肠道菌群在神经病理性疼痛中作用的研究进展[J]. 基础医学与临床, 2023, 43(1): 188-191.

LYU Yanhan, YU Zhuoying, LI Min. Research progress of gut microbiota in neuropathic pain[J]. Basic & Clinical Medicine, 2023, 43(1): 188-191.

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肠道菌群在神经病理性疼痛中作用的研究进展

Research progress of gut microbiota in neuropathic pain

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